Effects of Adansonia digitata and Corchorus olitorius Leaves Concoction on Selected Parameters Associated with Fried Oil–Induced Hepatic Damage in Rats

OOladapo Oyinkansola Precious
This study investigated the effects of aqueous leaves concoctions of Adansonia digitata and Corchorus olitorius on the serum proteins, antioxidants and the liver enzymes of rats administered with fried oil. A total of thirty-six (36) Wistar rats were distributed into 6 groups of 6 rats each, such that, all groups were fed on rat chow and distilled water. All other groups were administered with fried oil; groups 3, 4, and 5 were administered with aqueous leaves concoctions of A. digitata, C. olitorius, and the combination of both respectively. Group 6 was placed on Vitamin C. The secondary metabolites constituents of A. digitata and C. olitorius revealed the presence of saponins, alkaloids, flavonoids, tannins, terpenoids, steroids and polyphenols. The administration of fried oil significantly (p<0.05) altered cellular parameters associated with oxidative stress as shown in the control group (group 2). There was significant (P<0.05) increase in the activities of Superoxide dimutase (SOD), Catalase (CAT), Glutathione-Stransferase (GST), Glutathione peroxidase (GPx), Glutathione (GSH) and albumin on all the groups administered with the leaves concoctions when compared with control group (group 2) and the most effective is the combined concoction group (group 5). There was significant (P<0.05) decrease in total protein, bilirubin, Alanine aminotransferase (ALT), Aspartate aminotransferase (AST) and Alkaline phosphatase (ALP) in all the groups administered with the leaves concoctions when compared with control group (group 2) and the most effective is the combined concoction group (group 5). Hence, we can therefore conclude that the leaves of A. digitata and C. olitorius might be useful as nutraceuticals.
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Cite as: desci.ng.1308.2025
Uploaded on Nov 13, 2025, 11:21:59 AM

Notes

This research highlights the potential of Adansonia digitata (baobab) and Corchorus olitorius (ewedu) leaves as natural, affordable remedies for liver damage caused by fried oil consumption. Rich in antioxidants and bioactive compounds, these plants can protect and restore liver function, offering a scientific basis for their traditional use in herbal medicine. Their application supports community health, encourages local farming, and provides a cost-effective alternative to synthetic drugs. By promoting the medicinal value of these common African plants, the study strengthens the link between traditional knowledge and modern science for sustainable healthcare solutions.